antioxidant enzymes and oxidative stress in the erythrocytes of iron deficiency anemic patients supplemented with vitamins
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abstract
background: iron deficiency anemia is one of the major causes of morbidity and mortality worldwide. evidences from epidemiological and clinical studies suggest a possible correlation between antioxidant levels and the anemic disease risk. the present work is to investigate antioxidant levels and lipid peroxidation in anemic patients. methods: a number of 30 patients (15 males and 15 females) were selected for the study. likewise, 30 age- and gender-matched healthy volunteers (15 males and 15 females) were selected with their informed consent. patients and healthy subjects were supplemented with vitamins c and e for 15 days. the lipid peroxidation both in plasma and erythrocyte lysates was determined by thiobarbituric acid reactive substances and lipid peroxides. the antioxidant vitamins a, c, and e and total antioxidant activity were also analyzed. the antioxidant enzyme superoxide dismutase, catalase, and glutathione peroxidase were also determined. results: based on analysis, we found that the increase in lipid peroxidation was higher in the anemic subjects before vitamin supplementation, which was statistically significant at p<0.05. the antioxidant enzymes were higher in the patients before antioxidant supplementation when compared with patients after vitamin supplementation. conclusion: our data revealed higher oxidative stress before vitamin supplementation in iron deficiency anemic patients and after supplementation, lower lipid peroxidation and increased antioxidant vitamins were achieved.
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Journal title:
iranian biomedical journalجلد ۱۸، شماره ۲، صفحات ۸۲-۸۷
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